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. 2015 Apr 29;35(17):6893–6902. doi: 10.1523/JNEUROSCI.4002-14.2015

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Copyright © 2015 the authors 0270-6474/15/356893-10$15.00/0

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Figure 3. — NOS inhibition normalizes neurotransmitter release in 3xTg-AD neurons. A–C, Representative traces of postsynaptic spontaneous potentials recorded from NonTg (black) and 3xTg-AD (gray) CA1 neurons in aCSF (A), l-NAME (B), and SNAP (C). D, E, Bar graphs show averaged frequency (D) and amplitude (E) of spontaneous events from NonTg and 3xTg-AD neurons in aCSF, l-NAME and SNAP before (baseline) and 20 min after LFS (E-LTD); *p < 0.05 indicates significantly different from NonTg; **p < 0.05 indicates significantly different from control aCSF-treated neurons.