Table 2.

Effects of BPQ treatments on survival of N. caninum infected mice. On day 0, Balbc mice were infected by intraperitoneal injection of 2 × 10⁶ freshly purified N. caninum Nc-Liv tachyzoites. After 48 h, mice received buparvaquone (BPQ; 100 mg/kg) as suspension in corn oil either by intraperitoneal injection of a volume of 100 µl (i.p.), or orally by application of 100 µl by gavage (or). The control groups obtained the corresponding amount of the solvent only. The treatments were performed 5 times on a daily basis.

Group	No. of mice	Mortalitya	Time of death (day p.i.)
BPQ ip	6	2	7/7
Control i.p.	6	6	6/6/7/7/7/7
BPQ p.o	7	1	19b
Control p.o	6	4	7/8/9/9

^aNumber of mice killed upon severe acute disease signs.

^bEuthanized due to neurological signs of disease.