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. 2015 Apr 28;22(5):578–585. doi: 10.1128/CVI.00080-15

FIG 8.

FIG 8

Induction of antigen-specific IgG antibody in mice immunized with OVA-PIC NPs containing different cationic proteins. Mice (n = 3) were subcutaneously immunized twice with PBS, OVA-PIC (ε-PL) 100 μg (1 mg of γ-PGA-Phe, 200 μg of ε-PL, and 100 μg of OVA), OVA-PIC (ε-PL) 10 μg (100 μg of γ-PGA-Phe, 20 μg of ε-PL, and 10 μg of OVA), OVA-PIC (protamine) 100 μg (1 mg of γ-PGA-Phe, 200 μg of protamine, and 100 μg of OVA), or OVA-PIC (protamine) 10 μg (100 μg of γ-PGA-Phe, 20 μg of protamine, and 10 μg of OVA). Sera were collected on day 14 after the final immunization. The levels of OVA-specific IgG antibody were measured by ELISA. Data represent the means ± SD of the endpoint titers for groups of three mice. Statistical analysis was carried out among the results for the 5 groups (*, P < 0.05). n.s., not statistically significant.