TABLE 1.

Chlamydia proteins with antibody-reactive regions suitable for molecular serology

Protein	Locus taga	Sequence identity range (%)b	No. of peptides evaluatedc	No. of ARRs identifiedd	Referencese
OmpA/MOMP (outer membrane protein A)	CT_681	65–86	126	6	44, 58, 60–62, 64, 66, 74–77
PmpD (polymorphic outer membrane protein D)	CT_812	33–87	129	5	58, 60, 62, 66, 77, 79
CT618 (inclusion membrane protein CT618)	CT_618	23–72	41	3	59–61
IncA (inclusion membrane protein A)	CT_119	12–80	182	1	59–65, 81
CT529 (inclusion membrane protein CT529)	CT_529	31–88	33	1	59–62, 64
CrpA/Srp (cysteine-rich outer membrane protein A)	CT_442	20–88*	16	2	59–64
IncG (inclusion membrane protein G)	CT_118	41–45†	17	1	59–60
OmcB/Omp2 (outer membrane cysteine-rich protein B)	CT_443	71–99	24	2	44, 58, 60–62, 64, 77–78
TarP (translocated actin-recruiting phosphoprotein)	CT_456	24–92	20	1	60, 62–63, 66, 82
IncE (inclusion membrane protein E)	CT_116	53–59†	5	1	59–62, 64

^aThat is, the gene locus tag in the genome of C. trachomatis strain D/UW-3/CX.

^bRange of pairwise sequence identities among the nine Chlamydia spp. *, homolog not found in C. felis; †, homologs to the C. trachomatis protein found only in C. muridarum and C. suis.

^cPeptides were tested with mouse hyperimmune sera. Peptides from the following proteins did not react with mouse sera: CtrCpaf, CtrFtsH, CtrIncB, CtrIncC, CtrIncD, CtrLcrE, CtrIncF, CtrPmpB, CtrPmpC, CtrPkn5, CtrCT058, CtrCT089, CtrCT143, CtrCT147, CtrCT223, CtrCT226, CtrCT228, CtrCT228, CtrCT241, CtrCT381, CtrCT484, CtrCT541, CtrCT561, CtrCT579, CtrCT603, CtrCT619, CtrCT694, CtrCT741, CtrCT795, CtrCT813, CtrCT823, CtrCT875, Cpn0808, CpnPmp2, CpnPmp6, CpnPmp10, CpnPdhC, CpnPorB, CpnRecA, CpnRpsA, CpnRpsB, CpnYscC, CpnYscL, CpnYwbM, CpnCT858, Cpn0525, Cab063, CabCT058, CabCT541, CabIncAf, CabPmp15G, CpeCT143, CpeORF663, and CmuCT228.

^dAntibody-reactive regions (ARRs) that were identified with mouse sera.

^eKey references are cited.