Fig. (5).

Putative model for the regulation of the interaction between TRPV4 and STIM1 by phosphorylation on TRPV4 serine 824. TRPV4 WT can be activated by the interaction with proteins such as STIM1 through association/dissociation from its C-terminal cytoplasmic domain. The mechanism determining density of TRPV4 in the plasma membrane seems to be similar to that of other channels such as GLUT4 or AQP2. In contrast to TRPV4 S824A, S824D mutant cannot associate with STIM1 (for more detail, see the Discussion section).