Fig. 2.

A) Ramachandran plot of TGFBR3 mutant protein model. The most favored region, additional allowed regions, generously allowed regions and disallowed regions are indicated as red, yellow, light yellow and white respectively. B) H-bonding pattern and distances of (i) native Val451 and (ii) mutated residue Leu451 (yellow line indicates H-bonding distance in Å). The native residue Val451, atom CG2 formed bond with Ile445 of O atom with distance 2.7 Å, while mutated residue Leu451 of CD2 formed bond with Ile451 of O atom with distance 3.1 Å.