Table I.
The Microbiology of Neonatal Sepsis at Yale-New Haven Hospital, 2004–2013
| Early-Onset Sepsis* (42 episodes) | Late-Onset Sepsis* (368 episodes) | All Sepsis* (410 episodes) | |
|---|---|---|---|
| Gram-positive aerobic and facultative bacteria | |||
| Staphylococcus aureusa | 3 (7) | 64 (17) | 67 (16) |
| Coagulase-negative Staphylococcus speciesa | 2 (5) | 115 (31) | 117 (29) |
| Beta-hemolytic streptococci | |||
| Group B | 15 (36) | 17 (5) | 32 (8) |
| Group D | |||
| Enterococcus faecalis | 0 | 49 (13) | 49 (12) |
| Enterococcus faecium | 0 | 3 (0.8) | 3 (0.7) |
| Enterococcus spp | 0 | 9 (2) | 9 (2) |
| Viridans streptococcius speciesa,b | 1 (2) | 9 (2) | 10 (2) |
| Bacillus sppa | 0 | 2 (0.5) | 2 (0.5) |
| Listeria monocytogenes | 0 | 0 | 0 |
| Gram-negative aerobic and facultative bacteria | |||
| Escherichia coli | 19 (45) | 39 (11) | 58 (14) |
| Klebsiella pneumoniae | 0 | 23 (6) | 23 (6) |
| Klebsiella oxytoca | 0 | 9 (2) | 9 (2) |
| Haemophilus influenzae | 3 (7) | 0 | 3 (0.7) |
| Pseudomonas aeruginosa | 0 | 16 (4) | 16 (4) |
| Enterobacter cloacae | 0 | 13 (4) | 13 (3) |
| Enterobacter spp | 0 | 5 (1) | 5 (1) |
| Serratia marcescens | 0 | 4 (1) | 4 (1) |
| Acinetobacter baumannii | 0 | 3 (0.8) | 3 (0.7) |
| Citrobacter spp | 0 | 1 (0.3) | 1 (0.2) |
| Leclercia adenocarboxylata | 0 | 1 (0.3) | 1 (0.2) |
| Morganella morganii | 0 | 1 (0.3) | 1 (0.2) |
| Pantoea dispersa | 0 | 1 (0.3) | 1 (0.2) |
| Gram-negative anaerobic bacteria | |||
| Bacteroides spp | 0 | 0 | 0 |
| Fungi | |||
| Candida albicansa | 1 (2) | 9 (2) | 10 (2) |
| Candida dubliniensisa | 0 | 1 (0.3) | 1 (0.2) |
| Candida glabrataa | 0 | 1 (0.3) | 1 (0.2) |
| Candida lusitaniaea | 0 | 1 (0.3) | 1 (0.2) |
| Candida parapsilosisa | 0 | 7 (2) | 7 (2) |
| Malassezia pachydermatis | 0 | 2 (0.5) | 2 (0.5) |
| Yeastc | 0 | 3 (0.8) | 3 (0.7) |
| Organisms | 44 | 408 | 452 |
*
Number of times the organism was retrieved from blood culture (% of sepsis cases attributed to each organism)
a
Indicates a commensal species of bacteria or fungus
b
Includes Steptococcus mitis(2) and nonspeciated viridans streptococci(8)
c
Individual organisms not speciated