Figure 6. The structure of a CDK1–cyclin B-Cks2-ATP-competitive inhibitor complex.

The binding modes of Compound 23 to CDK1 (a) and to CDK2 (PDB code 2VTP) (b) are compared. The structures of the two complexes are drawn in the same orientation and selected active site residues are included. The inhibitor is drawn in ball and stick mode with carbon atoms coloured green. Hydrogen bonds are rendered as dotted lines.