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. Author manuscript; available in PMC: 2015 Oct 16.
Published in final edited form as: Nature. 2015 Apr 1;520(7547):353–357. doi: 10.1038/nature14347

Figure 3. Metastasis-to-metastasis seeding occurs either by a linear or a branching pattern of spread.

Figure 3

Body maps show the seeding of all tumour sites from (a) A22, (b) A21 and (c) A24. Sites shown include samples subject to targeted sequencing (A22-L, A24-F, A24-G) in addition to WGS samples. Seeding events are represented with arrows colour-coded according to Supplementary Table 3 and with double-heads when seeding could be in either direction. When the sequence of events may be ordered from the acquisition of mutations, arrows are numbered chronologically. Subclones on branching clonal lineages are labelled with the same number but with different letters, e.g. 4a & 4b. See Supplementary Information Section 4e for a detailed discussion of the body map in these cases.

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