Figure 4.

The relaxant effect of the HEMC in isolated rat aorta precontracted with phenylephrine. (a) Before and after incubation (30 min) with MDL-12,330A (10 μM, n = 5) or ODQ (1 μM, n = 6) in rings with functional endothelium. (b) Before and after incubation (30 min) with atropine (1 μM, n = 6) or propranolol (10 μM, n = 6) in rings with functional endothelium. The data points represent the mean ± SEM of the relaxing effect expressed as a percentage. Significant difference ^∗ P < 0.05; ^∗∗∗ P < 0.001 compared to control.