Table 1.
Effect of different inhibitors/antagonists on the relaxation induced by HEMC of rat aortic rings precontracted with phenylephrine.
| Groups | E max (% Relaxation) | IC50 (µg/mL) |
|---|---|---|
| Control E− | 4.1 ± 0.9 (6)*** | nd |
| Control E+ | 99.5 ± 1.4 (6) | 61.8 ± 6.9 |
| L-NAME | 13.8 ± 3.6 (8)*** | nd |
| Diclofenac | 84.5 ± 4.6 (7)** | 63.8 ± 5.1 |
| L-NAME + diclof. | 11.9 ± 1.8 (5)*** | nd |
| ODQ | 32.7 ± 3.8 (6)*** | 78.7 ± 6.3* |
| MDL-12,330A | 77.8 ± 5.8 (5)* | 62.7 ± 4.8 |
| Atropine | 96.7 ± 3.8 (6) | 62.8 ± 6.2 |
| Propranolol | 98.2 ± 4.9 (6) | 58.5 ± 5.9 |
Number between parentheses indicates the number of animals. Values are means ± S.E.M.
Asterisks compared to group E+ (ANOVA followed by Newman-Keuls multiple comparison test, * P < 0.05; ** P < 0.01; *** P < 0.001 (nd = not determined due to the intense inhibitory effect)).