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. 2015 Mar 25;13(4):1688–1697. doi: 10.3390/md13041688

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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(A) CDCA1-R1 overall fold. β-strands and α-helices are shown in cartoon representation and named as reported by [3]. Cd²⁺ is also depicted as purple sphere. The CDCA1 two-lobe architecture is highlighted by different colors: lobe 1 in blue and lobe 2 in green; (B) Enlarged view of the CDCA1-R1 active site. Cd²⁺ coordination sphere is shown.