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. 2015 Apr 13;13(4):2105–2123. doi: 10.3390/md13042105

Figure 3.

Figure 3

Effect of ATX on tubular apoptosis in rats post burn. Representative TUNEL stained images are shown for the various groups (A). The burn insults caused significant increases in green-fluorescent labelled nuclei in renal tubular cells of both burn and vehicle groups. The administration of ATX at different doses significantly decreased the number of green-fluorescent labelled nuclei post burn (B). LY294002 abolished the protective effect of ATX on apoptotic tubular cells (B). The indices of apoptosis in the different groups were consistent with the TUNEL staining results. The most effective ATX dose was 20 mg/kg. The sample size was n = 8 for each group. The results are expressed as the mean ± SD. * p < 0.05, ** p < 0.01, vs. sham; ## p < 0.01, vs. burn + vehicle; @@ p < 0.01, vs. burn + ATX 20 mg/kg group; ns p > 0.05.