Table 4.

Gross toxicity in C57BL/6 male mice (n = 3 per group) treated with TP3, TP4, tigecycline (TIG), or imipenem (IMP) via intramuscular injection into the left thigh. Toxicity was graded as follows: level 1 (narrowing of eyes), level 2 (crouching and huddling), or no effect.

Dose (mg/mouse)	Mice(n) Receiving TP3	Mice(n) Receiving TP4	Mice(n) Receiving IMP	Mice(n) Receiving TIG
0.1	3, no effect	3, no effect	3, no effect	3, no effect
0.5	3, no effect	3, no effect	3, no effect	3, no effect
1	3, no effect	3, no effect	3, no effect	3, no effect
1.5	3, no effect	2, no effect; 1, toxicity level 1	3, no effect	2, no effect; 1, toxicity level 1
2	2, no effect; 1, toxicity level 1	2, no effect; 1, toxicity level 1	2, no effect; 1, toxicity level 1	1, no effect; 1, toxicity level 1; 1, toxicity level 2