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. 2015 Apr 16;13(4):2376–2389. doi: 10.3390/md13042376

Figure 1.

Figure 1

Selective apoptosis induction by avarol in PDAC cells. (A) Structure of avarol; (B,C) Avarol treatment-induced apoptosis in PDAC cell lines but not normal cell lines. MEF, IMR90, HFL1, HEK293, A549, MCF7, U2OS, HCT116, AGS, KLM1, Panc-1, and PK1 cells were incubated with avarol at the indicated concentrations for 24 h. Data are presented as the mean ± standard deviation (SD) of three simultaneously performed experiments; (B) Cell viability was determined using MTT assays; (C) Panc-1, PK1, KLM1, MEF, and IMR90 cell lysates were subjected to immunoblotting with an anti-PARP antibody. PARP cleavage was used as an apoptosis marker.