Skip to main content
. 2014 Nov;6(11):a019331. doi: 10.1101/cshperspect.a019331

Figure 2.

Figure 2.

Homeotic transformations in PcG mutants of various species. (A–D) Drosophila melanogaster, (E,F) Mus musculus, (G,H) Arabidopsis thaliana. (A,B) Leg imaginal discs undergoing a transdetermination event as indicated by the expression of the wing-specific gene vestigial (marked by green fluorescent protein [GFP]). (C,D) Cuticles of a wild-type (C) and a Su(z)12 mutant embryo (D). In the Su(z)12 mutant embryo, all abdominal, thoracic, and several head segments (not all visible in this focal plane) are homeotically transformed into copies of the eighth abdominal segment because of misexpression of the Abd-B gene in every segment. (E,F) Axial skeleton of newborn wild-type (E) and Ring1A-/- mice (F). Views of the thoracic regions of cleared skeletons show bone (red) and cartilage (blue). The mutant displays anterior transformation of the eighth thoracic vertebra as indicated by the presence of an eighth (1–8) vertebrosternal rib, instead of seven (1–7) as in the wild type. (G,H) Wild-type (G) and clf-2 mutant (H) flowers. The wild-type flower shows the normal arrangement of sepals, petals, stamens, and carpels. In the clf-2 flower, petals are absent or reduced in number. (A,B, Courtesy of N. Lee and R. Paro; C,D, reprinted, with permission, from Birve et al. 2001, © Company of Biologists Ltd; E,F, reprinted, with permission, from Lorente et al. 2000, © Company of Biologists Ltd; G,H, courtesy of J. Goodrich.)