Figure 5.

Schematic representation of the core PcG and TrxG protein complexes and their functions at promoters. Drosophila PcG proteins are depicted as red ovals with selected mammalian orthologs indicated in gray text. (A) Components and function of the PRC2 and counteracting activities of TrxG proteins (light green). (B) Components and functions of PRC1 and dRING-associated factor (dRAF) and the counteracting activities of the BAP SWI/SNF, facilitates chromatin transcription (FACT) remodeling complexes, and SET-domain histone KMTs TRX and ASH1. The TrxG protein Kismet-L is a member of the chromatin-helicase-DNA-binding (CHD) subfamily of chromatin-remodeling factors, stimulating elongation of Pol II. (Adapted from Enderle 2011.)