Table 1.
Core PcG proteins in model systems
| Drosophila melanogaster | Mus musculus | Arabidopsis thaliana | Caenorhabditis elegans | ||
|---|---|---|---|---|---|
| PcG DNA binding proteins | |||||
| PHO | Pleiohomeotic | Zinc finger | YY1 | ||
| PHOL | Pleiohomeotic-like | Zinc finger | |||
| PSQ | Pipsqueak | BTB-POZ domain | |||
| DSP1 | Dorsal switch protein 1 | HMG domain protein | HMGB2 | ||
| PRC2 core proteins | |||||
| ESC | Extra sex combs | WD 40 repeats | EED | FIE | MES-6 |
| E(Z) | Enhancer of zeste | SET domain | EZH1/ENX2 EZH2/ENX1 |
CLF MEA SWN |
MES-2 |
| SU(Z)12 | Suppressor of zeste 12 | Zinc finger VEFS box |
SU(Z)12 | FIS2 VRN2 EMF2 |
|
| p55 | p55 | Histone-binding domain | RBAP48 RBAP46 |
MSI1 (MSI2/3/4/5) |
|
| PRC1 core proteins | |||||
| PC | Polycomb | Chromodomain | CBX2/M33 CBX4/MPC2 CBX6 CBX7 CBX8/MPC3 |
||
| PH | Polyhomeotic | Zinc finger SAM/SPM domain |
EDR1/MPH1/RAE28 EDR2/MPH2 (EDR3) |
SOP-2 | |
| PSC | Posterior sex combs | Zinc finger HTH domain |
BMI1 MEL18/RNF110/ZFP144 |
AtBMI1A AtBMI1B AtBMI1C |
MIG-32 |
| SCE/dRING | Sex combs extra/dRing | RING zinc finger | RING1/RING1A RNF2/RING1B |
AtRING1A AtRING1B |
SPAT-3 |