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Roles of Srs2/RECQ5, Mph1/Fml1/FANCM, and Rad54 in homologous recombination. (A) Srs2 and RECQ5 displace Rad51 from ssDNA, leading to suppression of inappropriate recombination events. (B) Mph1/Fml1/FANCM can (i) release the invading strand from the D-loop to promote SDSA, and (ii) mediate regression of a blocked replication fork to bypass a DNA lesion. (C) Rad54 stimulates Rad51-mediated D-loop formation and facilitates DNA synthesis via the release of Rad51 from the DNA joint.
