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Inactivation of the cellulose synthase gene bcsA restores virulence to an mgtC null mutant and increases virulence of WT Salmonella. Shown is survival of C3H/HeN mice injected intraperitonally with WT (14028s), mgtC (EL4), bcsA (MP140), or bcsA mgtC (MP142) Salmonella strains at doses of 1 × 104 CFU (A) and 1 × 105 CFU (B). WT vs. mgtC, P < 0.01; WT vs. bcsA, P < 0.01; bcsA vs. mgtC bcsA, not significant (N.S.), Mantel–Cox test. Results are representative of two independent experiments.
