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CARDS TX secondary structure. (A) Secondary structure observed crystallographically as a function of amino acid sequence. (B) The D1 mART domain lacking the steric block labeled according to A. The view is ∼90° around the horizontal relative to Fig. 1. (C) Divergent stereo pair in the same orientation as Fig. 1 showing the steric block of the NAD+-binding pocket, linker, and D2+D3 β-trefoil domain structural elements labeled as in A.
