Table 2.
Kd values of 4a and selected compounds to representatives of other PRDs
| Domain name | 4a | PP-ligand | ProM-ligand | |||
| Consensus | Kd, µM | Sequence | Kd, µM | Sequence | Kd, µM | |
| Fyn-SH3 | [RKY]..P..P | 5,900(900) | Ac-RALPPLP-NH2 | 18(5) | Ac-RAL[ProM-1]LP-NH2 | 62(13) |
| YAP1-WW | PP.Y | 330(60) | Ac-LPPPPYRHR-NH2 | 21(2) | Ac-L[ProM-1][ProM-1]YRHR-NH2 | 4.4(0.1) |
| Homer1-EVH1 | PP..F | 400(100) | Ac-ALTPPSPFRDS-NH2 | 72(5) | Ac-ALT[ProM-1]SPFRDS-NH2 | 800(100) |
| CD2BP2-GYF | [QHR]{0.1}P[LP]PP[GS]H[RH] | 3,200(600) | Ac-EFGPPPGWLGR-NH2 | 6.3(0.5) | Ac-EFGP[ProM-1/2]GWLGR-NH2 | N.D. |
Consensus motifs of the domains are in italics. Prolines replaced by the ProM-fragments are in bold. N.D., not detectable.