Trex1D18N/D18N mice have a shortened lifespan and an autoimmune phenotype. (A) Survival curve. (B) Spleen weight (three to eight animals per genotype). (C) Splenocyte cell counts (10 animals per genotype). (D) Spleen H&E. (Scale bar, 100 µm.) (E) Heart H&E. (Scale bar, 100 µm.) (F) Kidney H&E. (Scale bar, 50 µm; * indicates tubular proteinosis.) (G) Splenic vessel H&E. (Bar, 50 µm.) (H) Histology scores for inflammation. SG, salivary gland. (I) Histology scores for splenic lymphoid hyperplasia, vasculitis, and renal disease. ND, not detected. *P < 0.05; **P < 0.001; bars represent the mean, and error bars represent the SEM.