Fig. 2.

[F-18]FDDNP PET DVR value analysis separates mTBI, CTRL and AD groups. (A) A 3D scatter plot correlation of subcortical regions (dorsal midbrain) with limbic structures (amygdala) and cortical regions (frontal lobe) shows that all three groups (mTBI, green; AD, red; CTRL, blue) can be effectively separated based on the differences in binding patterns in these three areas. The mTBI group is significantly separated from control group in all three areas and from the AD group in the limbic and subcortical areas (Table 2). (B) A 3D scatter plot correlation of cortical structures alone, without comparison with subcortical or limbic structures, demonstrates that the mTBI group overlaps both with AD and CTRL groups. Results of discriminant analysis for the correlation of three areas depicted in each 3D scatter plot are shown underneath each graph.