Figure 10.
Effect of intraperitoneal LPS (0.1 mg/kg) and vehicle (saline; 10 ml/kg) on locomotion (A) and exploration (B) of female WT, PYY−/−, PYY+NPY−/− and NPY−/− mice. LPS or vehicle was injected in the morning of day 3 (9.00 – 9.30 h), and locomotion and exploration recorded during the following photo- and scotophase. The effect of LPS and its vehicle during the photophase and scotophase of day 3 was expressed as a percentage of the respective parameters measured in the photophase and scotophase of day 2, respectively. The values represent means ± SEM, n as indicated below the abscissa. x P ≤ 0.1, xx P ≤ 0.05 vs. day 2 (paired t-test); ## P ≤ 0.05 vs. vehicle-treated WT mice (two-sample t-test).