. Author manuscript; available in PMC: 2015 Apr 29.

Published in final edited form as: Front Biosci (Schol Ed). 2013 Jan 1;5:575–587. doi: 10.2741/s391

Table 1. NK receptor gene families in human and mouse genomes.

Gene Family	Human	Mouse	Function
KIRs	15 genes clustered in LRC on Chr. 19	2 genes on Chr. X	Ig-like receptor family members 9 inhibitory, 6 activating receptors in humans
LIRs	12 genes clustered in LRC on Chr. 19	none known	Ig-like receptor family members 5 inhibitory, 7 activating receptors in humans
Ly49	Psuedogene on Chr. 12	15 genes (C57BL/6 mice) clustered in NKC locus on Chr. 6	Type II lectin-like molecules 9 inhibitory, 2 activating receptors in mice
KLR (eg. CD94) and NKG2 families	4 genes in NKC region of Chr. 12	4 genes clustered in NKC locus on Chr. 6	C-type lectin-like receptors 4 inhibitory receptors in humans and mice

KIRs, killer immunoglobulin-like receptors; LIRs, Leukocyte Ig-like receptors; KLR, killer cell lectin-like receptor; LRC, leukocyte receptor complex; NKC, natural killer gene complex