Table 2.
Treatment by Outcome Interaction Results and Post hoc Analyses of Extracted Regions of Interest
| Region | MNI Coordinates, Peak
|
Side | Cluster Size,a Voxels | Effect Sizesb
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| X | Y | Z | REM-NR to CBT | REM-NR to sCIT | CBT-sCIT in NR | CBT-sCIT in REM | Average Marginal ES | |||
| Anterior insula | +30.0 | +24.0 | −13.5 | R | 529 | 1.69 | 1.17 | 1.52 | 1.33 | 1.43 |
| Inferior temporal (BA 20) | +42.0 | −33.0 | −25.5 | R | 469 | 1.23 | 1.45 | 2.09 | 0.59 | 1.34 |
| Amygdala | −27.0 | −7.5 | −27.0 | L | 233 | 0.98 | 1.61 | 1.89 | 0.69 | 1.29 |
| Premotor (BA 6) | −27.0 | +1.5 | +58.5 | L | 233 | 1.40 | 1.03 | 1.75 | 0.68 | 1.22 |
| Motor (BA 4) | +25.5 | −27.0 | +60.0 | R | 147 | 0.61 | 1.78 | 1.80 | 0.58 | 1.19 |
| Precuneus (BA 7) | −18.0 | −67.5 | +43.5 | L | 101 | 1.18 | 1.27 | 1.37 | 1.08 | 1.23 |
Abbreviations: BA, Brodmann area; CBT, cognitive behavior therapy; CBT-sCIT, mean difference between CBT and escitalopram oxalate (treatment effect); MNI, Montreal Neurological Institute; NR, nonresponders; REM, remitters; REM-NR, mean difference between remitters and nonresponders (remission effect); sCIT: escitalopram oxalate.
a
Whole-brain 2-way analysis of variance with P < .001 uncorrected; voxel size, 1.5 mm × 1.5 mm × 1.5 mm.
b
Effect size = mean difference divided by pooled standard deviation.