Figure 1.

Flow Diagram

Flow diagram of patients participating in OPT TMS trial. rTMS is repetitive transcranial magnetic stimulation. Phase 1 has been described in a previous paper¹. Phase 2 is the subject of this paper and includes both an open label active trial of Fast Left rTMS trial (Phase 2a) and an open label Slow Right rTMS trial (Phase 2b). Patients who remitted in each phase are shown moving to Phase 3. Other patients are either included as drop outs or shown moving to the next phase. For example, in Phase 2a (Active Fast Left rTMS) nine patients who were in the active arm in Phase 1 and 13 patients who were in the sham arm of Phase 1 remitted and moved to Phase 3. Thirty-eight patients dropped out or declined further treatment and 37 patients who were originally in the active arm of Phase 1 and 44 patients who were in the sham arm of Phase 1 consented to start Phase 2b (Active Slow Right rTMS). Phase 3 will be detailed in a manuscript under review and is the long term follow up of patients on a standardized medication trial to evaluate relapse rates after rTMS. Of the patients who remitted in either Phase 1, Phase 2a or Phase 2b sixty-one patients consented to participate in Phase 3.