Table 5.
Summary of pharmacokinetic parameters in the substudy
| Pharmacokinetic parameters | Darunavir | Cobicistat | Emtricitabine | Tenofovir |
|---|---|---|---|---|
| n = 60 | ||||
| AUCtau, ng•h/ml [mean (SD)] | 81,646 (26,322)* | 7596 (3657)* | 11,793 (3490)† | 3613 (1203)† |
| Cmax, ng/ml [mean (SD)] | 7663 (1920) | 991 (331) | 1862 (491)* | 382 (118)* |
| Ctau, ng/ml [mean (SD)] | 1311 (969)* | 33 (95)* | 113 (101)† | 78 (33)† |
| C0h, ng/ml [mean (SD)] | 1560 (1328) | 76 (186) | 147 (171)* | 84 (45)* |
| Tmax, h [median (Q1, Q3)] | 3.50 (2.49, 4.29) | 3.50 (2.01, 4.50) | 2.02 (2.00, 3.50)* | 2.00 (1.00, 3.05)* |
| t1/2, h [median (Q1, Q3)] | 7.24 (5.35, 11.54)‡ | 3.25 (2.91, 3.81)* | 7.14 (6.44, 7.86)§ | 13.34 (11.68, 15.35)§ |
*n = 59; †n = 58; ‡n = 55; §n = 56.