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. 2015 Mar 27;17(1):45. doi: 10.1186/s13058-015-0558-3

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© Tabariès et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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T lymphocytes are recruited to liver and lung metastases from breast cancer. Paraffin-embedded sections from primary breast tumors, bone specimens, lung specimens and liver specimens obtained following experimental metastasis assays were subjected to immunohistochemical staining with anti-CD3 antibodies. (A) Representative images from 20X, 40X magnifications for each site are shown. 40X images were taken at the margin of the lesions (40X margin) and in more distal regions (40X adj.). Scale bar represents 40 μm (20X) or 20 μm (40X) and applies to all panels of the same magnification. (B) Positivity of CD3 staining (expressed as a ratio of positive pixels over the total pixels per field) quantified inside lesions (TUMOR), in the adjacent tissue (ADJ) or in control (CTRL) samples without any lesions. Lymphocyte T expression and recruitment is mostly associated with lung or liver metastasis (^*: P <0.001).