Table 1. Pathway analysis of genes co-expressed with PDGFRα, PDGFRβ, and c-MYC in MB tumors.
PDGFRα | PDGFRβ | c-MYC | |||
---|---|---|---|---|---|
Antigen_processing_and_presentation | Adherens_junction | Ubiquitin_mediated_proteolysis | |||
Arachidonic_acid_metabolism | Amoebiasis* | Spliceosome | |||
Basal_cell_carcinoma | Antigen_processing_and_presentation | Ribosome_biogenesis_in_eukaryotes | |||
ECM_receptor_interaction | Apoptosis* | Ribosome | |||
Focal_adhesion | Cell_adhesion_molecules__CAMs* | Protein_processing_in_endoplasmic_reticulum* | |||
Hedgehog_signaling_pathway* | Complement_and_coagulation_cascades | Protein_export* | |||
Hippo_signaling_pathway | Cytokine_cytokine_receptor_interaction* | Olfactory_transduction* | |||
Insulin_secretion | ECM_receptor_interaction | Neuroactive_ligand_receptor_interaction | |||
Leukocyte_transendothelial_migration | Focal_adhesion | N_Glycan_biosynthesis* | |||
Lysosome | Hematopoietic_cell_lineage* | Measles* | |||
Neuroactive_ligand_receptor_interaction* | Inflammatory_bowel_disease__IBD_ | Jak_STAT_signaling_pathway* | |||
Pathways_in_cancer | Insulin_secretion | Glycolysis_Gluconeogenesis* | |||
Phagosome | Leukocyte_transendothelial_migration | Cytokine_cytokine_receptor_interaction | |||
PI3K_Akt_signaling_pathway | MicroRNAs_in_cancer* | ||||
Protein_digestion_and_absorption | NF_kappa_B_signaling_pathway* | ||||
Proteoglycans_in_cancer | Pathways_in_cancer | ||||
Regulation_of_actin_cytoskeleton | Phagosome | ||||
Ribosome* | PI3K_Akt_signaling_pathway | ||||
Staphylococcus_aureus_infection | Protein_digestion_and_absorption | ||||
Sulfur_metabolism* | Proteoglycans_in_cancer | ||||
Wnt_signaling_pathway* | Regulation_of_actin_cytoskeleton | ||||
Small_cell_lung_cancer* | |||||
Staphylococcus_aureus_infection | |||||
TNF_signaling_pathway* | |||||
Viral_myocarditis |
The major pathways identified from human MBs based on the highly co-expressed genes.
Genes in the pathways are specifically co-expressed with PDGFRα, or PDGFRβ, or c-MYC in MBs
The frequency of pathways found in 5 sets of data are marked as following: 2 out of 5: 3 out of 5: 4 out of 5: 5 out of 5: