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. 2014 Dec 18;6(5):2779–2793. doi: 10.18632/oncotarget.2995

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Copyright: © 2015 Loria et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) siMical-1/BRAF^V600Ecells were analyzed with Muse™ Caspase-3/7 assay. (B) Caspase-3/7 activity after transfection with siScr (black bars) or siMICAL1 (white bars) is reported. (C) Cells plated on poly-l lysine coated slides, stained with phalloidin-TRITC, and anti-H2B-pS14 that co-stains with Hoechst of apoptotic nuclei of siMical-1/BRAF^V600E cells. (D) Scale bar is 10 μm. Histogram reported the percentage of H2B-pS14 positive cells.