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. 2014 Dec 30;6(5):2827–2842. doi: 10.18632/oncotarget.3090

Figure 8. Expression of proteins involved in the apoptosis signaling pathways in MCF-7 and MCF-7/Adr cells, as determined by western blotting.

Figure 8

(1) Control (PBS); (2) free DOX; (3) DOX·HCL; (4) DOX nanoparticles; (5) targeted DOX nanoparticles; and (6) functional DOX nanoparticles. Activity ratios of caspase-3 and caspase-9 (A) and expression ratios of the pro-apoptotic proteins Bax and Bid and the anti-apoptotic proteins Bcl-2 and Bcl-xl (B) in MCF-7 and MCF-7/Adr cells after incubation with varying formulations. β-actin was also assessed by western blotting. All protein levels were quantified densitometrically and normalized to β-actin.