Table 1. miRNAs differentially expressed in normal tissues and colon cancer tissues, as determined by miRNA microarray analysis.
| miRNA | Chromosomal location | Fold change |
|---|---|---|
| has-miR-7 | 9q21.32 | 6.58 |
| hsa-miR-9-2 | 5q14.3 | 4.68 |
| has-miR-15a | 13q14.2 | 2.91 |
| has-miR-17 | 13q31.3 | 6.87 |
| has-miR-19a | 13q31.3 | 4.17 |
| has-miR-19b | 13q31.3 | 4.14 |
| has-miR-20a | 13q31.3 | 7.05 |
| has-miR-20b | Xq26.2 | 6.50 |
| has-miR-21 | 17q23.1 | 3.60 |
| has-miR-25 | 7q22.1 | 2.74 |
| has-miR-27a | 19p13.13 | 2.78 |
| has-miR-29a | 7q32.3 | 3.21 |
| has-miR-29b | 7q32.3 | 5.49 |
| has-miR-34a | 1p36.22 | 3.51 |
| has-miR-34b | 11q23.1 | 2.34 |
| hsa-miR-93 | 7q22.1 | 3.14 |
| has-miR-106a | Xq26.2 | 5.55 |
| has-miR-106b | 7q22.1 | 3.49 |
| has-miR-146a | 5p34 | 3.54 |
| has-miR-139 | 11q13.4 | 0.53 |
| has-miR-181c | 19p13.13 | 2.99 |
| has-miR-196b | 7p15.2 | 7.18 |
| has-miR-224 | Xq28 | 11.34 |
| has-miR-374 | Xq13.2 | 2.88 |
| hsa-miR-375 | 2q35 | 0.33 |
| has-miR-424 | Xq26.3 | 10.61 |
| has-miR-452 | Xq28 | 3.42 |
| has-miR-590 | 7q11.23 | 3.49 |
| has-miR-622 | 13q31.3 | 2.56 |
| has-miR-630 | 15q24.1 | 2.94 |
| has-miR-765 | 1q23.1 | 2.49 |
Four colon cancer tissue samples and matched normal colon tissue samples were analyzed twice with miRNA microarray. All differentially expressed miRNA had a q value < 0.01 (false-positive rate). All, except hsa-miR-139 and has-miR-375, were up-regulated in colon cancer tissues.