Figure 4. RNA-seq analysis of A375 stable cells reveals a correlation between EZH2 catalytic activity and global gene expression patterns.
(A) Hierarchical clustering analysis of mRNA expression levels of A375 stable cell lines, including A375 Y641F + GSK126 (left column), is displayed. Red color indicates high gene expression values and blue color indicates low gene expression values (standardized values). (B) A table containing the results from Gene Set Enrichment Analysis is displayed. Left column: A375 Y641F versus vector control cells. Right column: GSK126-treated A375 Y641F versus A375 Y641F.