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(A) CD44 siRNA affects both mRNA and protein levels. (B-C) CD44 silencing inactivates the (B) ERK and (C)AKT pathways. (D-E) CD44 silencing inactivates YAP without affecting the nuclear-to-cytoplasmic translocation of YAP after the cells reach confluence. (F) CD44 silencing activates tumor suppressor function of NF2. (G) CD44 silencing activates tumor suppressor function of LATS1/2 not MST1/2. *p<0.05.
