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. 2014 Dec 30;6(5):2951–2965. doi: 10.18632/oncotarget.3095

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Copyright: © 2015 Yu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A-B) CD44 silencing inhibits cell proliferation (A) and downregulates PCNA and Ki67(B). (C-D) CD44 modulates cell cycle progression (C) and the expression of key cell cycle genes, Cyclin E2, Cyclin D1 and Cdk1(D). (E-F) Effects of PI3K inhibitor LY294002, AKT inhibitor MK-2206 and ERK inhibitor PD0325901 on CDK1 and its activity. *p<0.05.