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. 2014 Dec 30;6(5):2951–2965. doi: 10.18632/oncotarget.3095

Figure 6. CD44 modulates stemness.

Figure 6

(A) MDA-MB-435s are almost all CD44+/CD24-(Low) cancer stem cell-like cells. (B) Inhibition of tumorsphere formation upon silencing CD44. (C) Quantification of tumorspheres (size >50μm) upon CD44 silencing. “n” represents the number of spheres with size >50μm formed amongst 1000 cells examined. ***p<0.0001. (D) Inhibition of colony formation upon silencing CD44. (E) Quantification analysis of number of colony forming in plate colony forming assay.*p<0.05. (F-G) Abrogation of tumor formation ability upon CD44 depletion in mouse model. *p<0.05 (H-I) Effects of silencing CD44 on the expression of key regulatory genes of stemness. *p<0.05.