Figure 4. Sunitinib prevents C26-induced cachexia.

A, C26 cells (1×10⁶) were inoculated subcutaneously in the upper right flank of BALB/c mice. Tumor and body weight are plotted over time and their correlation is shown. B-C, C26-bearing mice were randomized (TW 100 mg) to receive sunitinib (40 mg/kg, p.o.) or vehicle (n=12 /group) daily for the indicated time; tumor growth (B) and body weight (C) are reported. Open arrow = treatment starts, full arrow = treatment ends. D, Body weight of animals with tumors at the same size (approx. 280 mg, irrespectively of the time after tumor transplantation) (n=7/group) is reported. Median tumor weight and day with range are reported.