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. 2014 Dec 26;6(5):3240–3253. doi: 10.18632/oncotarget.3087

Figure 1. KITENIN expression in human glioma samples.

Figure 1

(A) Western blotting analysis showing that the overall expression of KITENIN tended to increase along the sequence from normal brain tissues to low-grade gliomas (WHO grades I-II), and then to high-grade gliomas (WHO grades III-IV). (B) qRT-PCR showing that the levels of expression of KITENIN mRNA were significantly higher in glioma tissues than in normal brain tissues (P=0.010). (C) Relative KITENIN mRNA levels, normalized to GAPDH mRNA levels, were significantly higher in tumor than in normal tissue (P=0.037). (D) Immunohistochemistry with anti-KITENIN antibody on human glioma tissue samples showing cytoplasmic positivity, with representative figures according to staining intensity. (E) KITENIN expression, represented by the staining intensity from WHO tumor grade I through to grade IV, showing statistically significant differences between tumor grade groups (P=0.001, Table 5). The bar graphs show the mean ± the standard error of the mean (SEM) for each group. (*P<0.05, **P<0.01).