Figure 6. Model represents the activation of autophagy, formation of autophagosomes and release of exosomes from the rotenone treated CSCs.

Rotenone induces autophagic vacuolation in CSCs which are associated with the mitochondrial damage. These processes induce the formation of autophagosomes and autophagy in CSCs. Autophagosomes combine with the protein complexes, ribosomes, endoplasmic reticulum and peroxisomes, and form multi-vesicular endosomes. The multi-vesicular endosomes release exosomes.