Table 3.
Patients with LHON with white matter lesions
| Diagnosis | Sex | Age | Genetic mutation | Number of relapses (increased optic neuritis) | Number of T2 white matter lesions on MRI | MRI consistent with MS | ||
|---|---|---|---|---|---|---|---|---|
| Rater | ||||||||
| 1 | 2 | 3 | ||||||
| LMS | M | 42 | 14484 | >2 | 19 | Y | Y | N |
| LMS | F | 41 | 11778 | >2 | >20 with confluence | Y | Y | Y |
| LMS | M | 36 | 11778 | >2 | 1 (Confluent) | Y | Y | Y |
| LMS | M | 45 | 11778 | >2 | 3 | Y | Y | Y |
| LMS | F | 61 | 11778 | >2 | 2 | Y | N | Y |
| LMS | F | 36 | 11778 | 3 with secondary progression | >20 | Y | Y | Y |
| LMS | F | 50 | 3460 | 4 | 1 (Confluent) | Y | Y | Y |
| LMS | F | 34 | 11484 | 3 with secondary progression | 12 | Y | Y | Y |
| LMS | F | 48 | 11778 | 4 | 2 | Y | N | Y |
| LMS | F | 33 | 11778 | 2 | >20 | Y | Y | Y |
| LMS | F | 32 | 11778 | 2 | >15 | Y | Y | Y |
| LHON | F | 33 | 3460 | NA | 12 | Y | Y | Y |
| LHON | F | 41 | 11778 | NA | >20 | Y | Y | Y |
| LHON | F | 46 | 11778 | NA | 3 | N | N | Y |
| LHON | M | 40 | 11778 | NA | 2 | N | N | N |
| LHON | M | 50 | 11778 | NA | 8 | N | N | N |
| LHON | M | 22 | 11778 | NA | 4 | N | N | N |
| LHON | M | 68 | 11778 | NA | 6 | N | N | N |
| LHON | M | 25 | 11778 | NA | 10 | N | N | N |
LHON, Leber's hereditary optic neuropathy; LMS, MS-like disease in association with LHON; MS, multiple sclerosis.