Table 1.
A cross-sectional comparison of baseline patient characteristics according to the rs6677604 genotype and mesangial C3 deposition
| Characteristics | Total | rs6677604 | Mesangial C3 Deposition | ||||||
|---|---|---|---|---|---|---|---|---|---|
| AA | AG | P Value | 0 | 1+ | 2+ | 3+–4+ | P Value | ||
| Patient numbers | 365 | 39 | 326 | 28 | 47 | 114 | 176 | ||
| Age (yr) | 34.09±11.98 | 35.10±11.98 | 33.97±11.99 | 0.58 | 37.32±15.88 | 34.45±14.3 | 32.45±11.13 | 34.54±11.06 | 0.22 |
| Sex (men/women) | 194/171 (53.2%/46.8%) | 22/17 (56.4%/43.6%) | 172/154 (52.8%/47.2%) | 0.67 | 16/12 (57.1%/42.9%) | 24/23 (51.1%/48.9%) | 64/50 (56.1%/43.9%) | 90/86 (51.1%/48.9%) | 0.81 |
| eGFR (ml/min) | 85.87±36.57 | 90.63±31.08 | 84.93±32.52 | 0.30 | 91.75±50.50 | 88.52±28.60 | 87.48±26.47 | 82.50±33.15 | 0.34 |
| Proteinuria (g/d) | 1.40 (0.80, 2.69) | 1.51 (0.58, 2.59) | 1.40 (0.78, 2.71) | 0.55 | 1.38 (0.79, 4.91) | 1.82 (0.75, 3.43) | 1.42 (0.77, 2.45) | 1.40 (0.81, 2.52) | 0.70 |
| SBP (mmHg) | 124.2±14.3 | 121.3±14.0 | 124.6±14.3 | 0.17 | 124.5±11.4 | 126.5±21.0 | 122.8±12.8 | 124.5±13.5 | 0.50 |
| DBP (mmHg) | 79.2±11.0 | 79.6±12.1 | 79.1±10.9 | 0.78 | 78.8±9.4 | 79.2±14.4 | 77.6±10.5 | 80.2±10.5 | 0.26 |
| Oxford classification | |||||||||
| M (M0/M1) | 106/257 (29.2%/70.8%) | 11/28 (28.2%/71.8%) | 95/229 (29.3%/70.7%) | 0.89 | 13/15 (46.4%/53.6%) | 23/24 (48.9%/51.1%) | 40/74 (35.1%/64.9%) | 30/144 (17.2%/82.8%) | <0.001a |
| E (E0/E1) | 140/223 (38.6%/61.4%) | 15/24 (38.5%/61.5%) | 125/199 (38.6%/61.4%) | 0.99 | 10/18 (35.7%/64.3%) | 19/28 (40.4%/59.6%) | 38/76 (33.3%/66.7%) | 73/101 (42.0%/58.0%) | 0.45a |
| S (S0/S1) | 98/265 (27.0%/73.0%) | 13/26 (33.3%/66.7%) | 85/239 (26.2%/73.8%) | 0.84 | 13/15 (46.4%/53.6%) | 15/32 (31.9%/68.1%) | 29/85 (25.4%/74.6%) | 41/133 (23.6%/76.4%) | 0.02a |
| T (T0/T1/T2) | 278/46/39 (76.6%/12.7%/10.7%) | 34/4/1 (87.2%/10.3%/2.6%) | 244/42/38 (75.3%/13.0%/11.7%) | 0.17 | 26/2/0 (92.9%/7.1%/0.0%) | 39/4/4 (83.0%/8.5%/8.5%) | 85/20/9 (74.6%/17.5%/7.9%) | 128/20/26 (73.6%/11.5%/14.9%) | <0.01 |
a
P value for the linear-by-linear association chi-squared test.