Figure 5.

Tenapanor reduces urinary phosphate excretion in NPX rats. NPX rats fed a 4% NaCl diet were dosed with vehicle or tenapanor daily for 4 weeks. Weekly 24-hour urine collections were measured for phosphate using ion chromatography, and data are represented by (A) mass (micromoles per day) and (B) fractional excretion of phosphate (percentage). Data are represented by means±SEMs, and significance versus vehicle treatment determined by two-way ANOVA with Dunnett post hoc test is denoted by asterisks. Closed circle and dotted line, 3.0 mg/kg tenapanor interventional treatment paradigm (Tx paradigm); closed square, 3.0 mg/kg tenapanor prophylactic paradigm; open circle, vehicle; open square, 0.3 mg/kg tenapanor; split square, 1.0 mg/kg tenapanor. *P≤0.05; **P≤0.01; ***P≤0.001.