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Tenapanor improves uremic markers in the rat CKD model at the time of euthanasia. At euthanasia, blood was collected from rats fed chow with or with out tenapanor (5 mg/kg per day) for plasma from the remaining rats in the study and measured for (A) P, (B) Ca, (C) FGF-23, (D) creatinine, (E) albumin, and (F) BUN. Data are represented by means±SEMs, and mean comparison analysis was determined by t test with statistical significance denoted by asterisks. *P≤0.05; ***P≤0.001.
