Table 2.

Body weight, degree of stenosis, PRA, renal vascular resistance, ET-1 levels (renal vein blood stenotic kidney), excretion of nephrin (urine), and renal cortical and medullary volumes (means±SEMs) in normal pigs (n=7), RVD pigs (n=7), and RVD pigs before PTRAS and treatment with ET-A (n=7) and ET-A/B (n=5) receptor blockers

Parameter	Normal	RVD+PTRAS	RVD+PTRAS+ET-A	RVD+PTRAS+ET-A/B
Body weight (kg)	55.6±1.8	59.2±2.3	48.4±7.5	59.5±2.7
Degree of stenosis (%)	0.0±0.0	6.7±3.7	9.6±5.2	10.6±5.8
PRA (ng/ml per hour)	0.23±0.05	0.28±0.04	0.29±0.02	0.26±0.09
RVR (mmHg/ml per minute)	0.19±0.06	0.25±0.04	0.17±0.08a	0.39±0.07b,c,d
ET-1 (pg/ml)	0.91±0.05	2.6±0.5b	2.2±0.2b	8.7±0.6b,c,d
Nephrin (μg/ml urine)	0.4±0.2	3.2±0.6b	1.1±0.4c	2.7±0.6b,d
Cortical volume (cc)	114.7±4.0	94.1±1.2b	118.9±21.6c	91.1±10.1a,b
Medullary volume (cc)	32.9±1.3	29.4±2.7	35.7±7.9	23.8±3.7b,c,d

Parameters were obtained 4 weeks after PTRAS and placebo/ET receptor blocker therapy at 10 weeks. RVR, renal vascular resistance.

^aP>0.05 but P<0.10 versus RVD+PTRAS or RVD+PTRAS+ET-A (trend).

^bP<0.05 versus normal.

^cP<0.05 versus RVD+PTRAS.

^dP<0.05 versus RVD+PTRAS+ET-A.