Table 1.

On and off neurons and associated brain disorders.

Behavioral domain	Brain regions (On and Off switches)	Related brain disorders
Fear	Amygdala (fear-expression and intercalated neurons)	Posttraumatic stress disorder
Motor control	Striatum (dopamine D1 and D2 neurons)	Parkinson's disease and schizophrenia.
Working memory	Striatum (dopamine D1 and D2 neurons)	–
Episodic memory	Dorsolateral prefrontal cortex	–
Sleep	Lateral hypothalamus (melanin-containing and orexin neurons)	Insomnia, narcolepsy