Figure 1.

A scatter plot showing plasma neurofilament heavy chain protein (NfH) levels in cross-sectional cohort. There was no significant difference in total plasma NfH (lime green), NfH^SMI34 (strong blue) and NfH^SMI35 (pure blue) between 136 patients with amyotrophic lateral sclerosis (ALS; squares) and 104 controls (healthy and disease controls; circles). If patients with ALS were grouped according to the disease duration from onset to baseline sampling, a trend towards an increased level of NfH-phosphoforms in patients with the shortest disease duration (0–12 months, n=31) compared with controls was noted for total NfH (p=0.059) and for NfH^SMI35 (p=0.055). Error bars: median±IQR. Mann–Whitney U test.