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. 2015 Apr 29;6:165. doi: 10.3389/fgene.2015.00165

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Copyright © 2015 Angrand, Vennin, Le Bourhis and Adriaenssens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The multifaceted action of the lncRNA H19. The lncRNA H19 controls genome expression at multiple levels. H19 acts on chromatin organization through the recruitment of chromatin modifying complex PRC2 (1) and on post-transcriptional control as a miR decoys sequestering miR-106a and miR-let7 (2) or as a precursor for miR-675-5p and miR-675-3p (3) H19 also interact with p53 (TP53) and inactivate the tumor suppressor protein action (4) Furthermore, possible base pairing between H19 and the antisense transcripts 91H and HOTS may have biological outcomes (5).