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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Sci Signal. 2015 Feb 24;8(365):ra20. doi: 10.1126/scisignal.2005648

Figure 6. PECAM-1 is required for oxidant stress-induced proinflammatory responses.

Figure 6

(A/B) HAECs transfected with PECAM-1 siRNA were treated with H2O2 for the indicated times and analyzed for phosphorylated NF-κB (A, B) and VCAM-1 abundance (A, C) by Western blotting. Representative Western blots are shown. n=5 independent experiments. *** p<0.001, **** p < 0.0001. (D) Model of oxidant stress-induced activation of NF-κB activation through PECAM-1-dependent recruitment of Nck.